Pharmaceutical companies have long relied on a costly and time-consuming trial-and-error process to discover new drugs. However, Dompé Farmaceutici is leading the way in developing new medication for diseases like COVID-19 by using cutting-edge technology called "computational chemistry". This innovative approach has allowed them to process a massive dataset of 42 billion rows of data, which grows by 10% annually, and accelerate the drug discovery process like never before. To achieve this, Dompé Farmaceutici evaluated different non-SQL DB engines but found that their performance and efficiency were lacking for structured data. Traditional SQL DBs were also not scalable enough and had poor performance. After careful consideration, they ultimately chose MariaDB's ColumnStore enterprise version, which allows them to scale to a multi-node system and keep up with the rapid growth in their dataset without sacrificing performance. Thanks to this cutting-edge technology, Dompé Farmaceutici is leading the charge in the world's most important drug discovery initiative backed by the European Commission. By utilizing MariaDB's ColumnStore, they are well-equipped to develop new medication that will change the game in the fight against COVID-19 and other diseases.